- Kaley is best friends with Jodi Lyn O'Keefe. Both play on Charmed and the Big Bang Theory.
- Kaley Cuoco was a regular on Charmed with Ted King. However Kaley was a regular in season 8 and Ted in season 1. Both are 2 degrees from each other.
- Kaley has been married to tennis player Ryan Sweeting since 2013.